Mammalian beta 1- and beta 2-adrenergic receptors. Immunological and structural comparisons.
نویسندگان
چکیده
منابع مشابه
Mammalian PI - and & Adrenergic Receptors IMMUNOLOGICAL AND STRUCTURAL COMPARISONS
6,and b2-adrenergic receptors, pharmacologically distinct proteins, have been reported to be structurally dissimilar. In the present study three techniques were employed to compare the nature of mammalian &and Bz-adrenergic receptors. Antibodies against each of the receptor subtypes were raised separately. Polyclonal antisera against &-receptors f rat fat cells were raised in mice, and antisera...
متن کاملBeta-Adrenergic Receptors
ion fluxes in these cells, we have now examined the possibility that the decrease in beta receptor number might be associated with concomitant changes in catecholamine-dependent potassium ion transport. Hypothyroid turkey erythrocytes display decreased sensitivity to isoproterenol-stimulated potassium influx. Half-maximal stimulation of potassium influx occurs at 9.2±+1.7 nM in hypothyroid cell...
متن کاملBeta-Adrenergic Receptors and Fat Loss
HISTORY OF MESOTHERAPY This review of basic pharmacology using ephedrine as an active medication is provided by Bryan Haycock, MS, CSCS, founder of HSN. As a sympathomimetic, ephedrine acts to stimulate the sympathetic nervous system. It does this by causing presynaptic nerve terminals to release norepinephrine, or what is commonly called noradrenaline (NA), into the synaptic space. It also has...
متن کاملBeta-2 adrenergic receptor
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream Ltype calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Unlike other adr...
متن کاملIdentification of a beta 2-adrenergic receptor in mammalian epidermis.
The presence of a betaz-adrenergic receptor in the epidermis has been demonstrated, based on the following pieces of information: (I) the addition of salbutamol, a betas-agonist, to slices of epidermal tissue increased the levels of cyclic AMP in the tissue above control levels in a dose-dependent manner with a maximum response after 5 min of incubation in 5 x lo-’ M salbutamol, (2) the additio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1986
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)66907-8